PSIV-B-15 Effects of Different Prenatal Nutrition Strategies on Liver Metabolome of Bulls and its Correlation with Body and Liver Weight

Abstract The impacts of maternal nutrition throughout the life offspring have been studied in last decades. However, some molecular mechanisms and responses involved fetal programming beef cattle remain unclear. This study investigated effect different prenatal strategies on liver metabolome body weight Nellore bulls at slaughter. For that purpose, three nutritional treatments were applied 126 cows during pregnancy: NP – (control) only mineral supplementation; PP protein-energy supplementation third trimester; FP entire pregnancy. pre-slaughter from male evaluated a targeted metabolomics analysis (AbsoluteIDQ p180 Kit; 180 metabolites) was performed (n = 18, 22.5 ± 1 months age). Data submitted to principal component (PCA), variance (ANOVA), enrichment Pearson’s correlation analysis. phenotypes did not show differences among (p > 0.05). Metabolites PCA showed an overlap clusters We found metabolites significant ANOVA ≤ 0.05; Glycine, Hydroxytetradecadienylcarnitine, Aminoadipic acid Carnosine). Enrichment revealed biological processes Histidine metabolism, beta-Alanine metabolism Lysine degradation). 29 correlated with 0.05) metabolite (Symmetric dimethylarginine; r 0.51; p In summary, effects evaluated, but affected pathways mainly related oxidative metabolism. addition, seems influence hepatic more than weight, due amount magnitude correlations found.